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It has a narrow therapeutic index; colchicine doses of 0.
Information about Colchicine.
Patients with renal or hepatic impairment should not be given colchicine capsules with drugs that inhibit both P-glycoprotein and CYP3A4See CONTRAINDICATIONSCombining these dual inhibitors with colchicine capsules in patients with renal and hepatic impairment has resulted in life-threatening or fatal colchicine toxicity.
If co-administration of colchicine capsules and a P-gp inhibitor is necessarythe dose of colchicine capsules should be adjusted by either reducing the daily dose or reducing the dose frequencyand the patient should be monitored carefully for colchicine toxicitySee CLINICAL PHARMACOLOGY
Tell your healthcare provider if you have any side effect that bothers you or that does not go away.
Dose reduction or alternatives should be considered for the prophylaxis of gout flares in patients with severe hepatic impairment.
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27 colchicine in combination with probenecid has been fda-approved prior to 1982.